Seven-year-old Stink Moody, having discovered that he can get free samples by writing letters of complaint to companies, gets so caught up in his letter writing campaign that he misses his best friend's birthday, but he plans a super surprise to make up for his mistake.

Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to relinquish his favorite, Astro.

After second-grader Stink gets an unsatisfactory grade in physical education, his parents tell him he must play a sport and so he masters thumb wrestling, as seen on a sports channel.

Stink has been in the Polliwog swim class for what seems like frog-ever, and still can't bear to put his face in the water. Then, one day, Stink has a close encounter with a freaky mutant frog. All of a sudden, his froggy senses are tingling!

Stink may be a super science freak, but even Dr. Stinkelstein is feeling freaked out about having a slime mold living and growing in his very own room. At Saturday Science Club, Stink learns that these one-celled organisms are smart enough to find their way out of mazes and gang up on food sources.

"Creepy! Crawly! Criminy! Stink is bonkers about most scientific things. But dangle a spider in front of him and he goes berserk! Stink is so freaked out by spiders that he can't read about them. He can't look at them. He can't think about them. And he for sure can't touch them! Stink has arachnophobia (a fear of spiders), and he has it bad. But when a hairy backyard emergency arises, Stink is forced to face his fear--and eight beady eyes--head-on....